Specific iron chelators determine the route of ferritin degradation
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چکیده
منابع مشابه
Specific iron chelators determine the route of ferritin degradation.
Deferoxamine (DFO) is a high-affinity Fe (III) chelator produced by Streptomyces pilosus. DFO is used clinically to remove iron from patients with iron overload disorders. Orally administered DFO cannot be absorbed, and therefore it must be injected. Here we show that DFO induces ferritin degradation in lysosomes through induction of autophagy. DFO-treated cells show cytosolic accumulation of L...
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Ferritin is a cytosolic molecule comprised of subunits that self-assemble into a nanocage capable of containing up to 4500 iron atoms. Iron stored within ferritin can be mobilized for use within cells or exported from cells. Expression of ferroportin (Fpn) results in export of cytosolic iron and ferritin degradation. Fpn-mediated iron loss from ferritin occurs in the cytosol and precedes ferrit...
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Iron release from both human and horse spleen haemosiderin to desferrioxamine was substantially less than that released from ferritin samples. This finding contradicts a previous report [Kontoghiorges, Chambers & Hoffbrand (1987) Biochem. J. 241, 87-92]. Differences in phosphate content of cores and in core size between haemosiderin and ferritin did not account for the different iron-release ra...
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1. Díez JJ, Iglesias P. The role of the novel adipocyte-derived hormone adiponectin in human disease. Eur J Endocrinol. 2003;148:293-300. 2. Leth H, Andersen KK, Frystyk J, Tarnow L, Rossing P, Paeving HH, et al. Elevated levels of high-molecularweight adiponectin in type 1 diabetes. J Clin Endocrinol Metab. 2008;93:3186-91. 3. Oh DK, Ciaraldi T, Henry RR. Adiponectin in health and disease. Dia...
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مقدمه: در تالاسمی ماژور به دلیل لیز بیش از حد سلولی بیماران دچار اضافه بار آهن خواهند شد. برای جلوگیری از عوارض اضافه بار آهن در بدن از آهن زداها استفاده می شود. آهن زداهای رایج مورد استفاده دفروکسامین، دفریپرون و دفراسیروکس می باشند. این مطالعه قصد دارد علاوه بر بررسی سطح فریتین سرم به مقایسه بین اثرات آهن زدا ها در کاهش سطح فریتین سرم در بیماران مبتلا به تالاسمی ماژور شهر یاسوج که در طی یکسال...
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ژورنال
عنوان ژورنال: Blood
سال: 2009
ISSN: 0006-4971,1528-0020
DOI: 10.1182/blood-2009-05-224188